This Historic Resource Study (HRS) provides a historic context for, and identifies, sites in south Florida related to the Cold War and U.S. relations with Latin America. The report focuses on resources in and near the four national parks located in the region: Everglades National Park (Everglades NP), Biscayne National Park (Biscayne NP), Big Cypress National Preserve (Big Cypress NP), and Dry Tortugas National Park (Dry Tortugas NP). The study identifies structures, remains of structures, and landscapes where activities associated with the Cold War are reported to have taken place. This HRS pays particular attention to sites related to the events mentioned above as well as resources associated with the large Cuban exile population of south Florida. The historic context provides the basis for future nominations to the National Register of Historic Places. The HM- 69 Nike base within Everglades National Park was listed in the National Register in 2004.