Truck driver Joshua Kaine and his wife, Jessie, enjoy the freedom of the open road, until the night Josh is attacked by a rabid dog. Josh kills the animal, but his and Jessie's troubles have only just begun.
Following the attack, Josh becomes deathly ill, but three weeks later he's feeling much better - much stronger - much more alive. When the moon rises full and bright, Josh experiences the change for the first time, his body morphing into that of a large, gray wolf. His appetite - for both food and sex - is enormous, and he spends every waking moment feeding his hunger.
Jessie doesn't know what's come over her husband, but she's not complaining. At least, not until a clan of werewolves comes after her and her family, intent upon seeking revenge for the death of their leader.
From a remote mountaintop to the swamps of Louisiana, Josh searches for a solution to their dilemma, but time is running out. When the absolute worst happens, Josh is forced to turn the tables and the hunted becomes the hunter.